The Exposome and Asthma

Ahila Subramanian; Sumita B Khatri

doi:10.1016/j.ccm.2018.10.017

The Exposome and Asthma

Clin Chest Med. 2019 Mar;40(1):107-123. doi: 10.1016/j.ccm.2018.10.017. Epub 2018 Dec 20.

Authors

Ahila Subramanian¹, Sumita B Khatri²

Affiliations

¹ Department of Allergy and Clinical Immunology, Respiratory Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, CWRU School of Medicine, 9500 Euclid Avenue/A90, Cleveland, OH 4419, USA.
² Department of Pulmonary and Critical Care Medicine, Respiratory Institute, Cleveland Clinic, Cleveland Clinic Lerner College of Medicine, CWRU School of Medicine, 9500 Euclid Avenue/A90, Cleveland, OH 4419, USA. Electronic address: khatris@ccf.org.

PMID: 30691706
DOI: 10.1016/j.ccm.2018.10.017

Abstract

This article on exposome and asthma focuses on the interaction of patients and their environments in various parts of their growth, development, and stages of life. Indoor and outdoor environments play a role in pathogenesis via levels and duration of exposure, with genetic susceptibility as a crucial factor that alters the initiation and trajectory of common conditions such as asthma. Knowledge of environmental exposures globally and changes that are occurring is necessary to function effectively as medical professionals and health advocates.

Keywords: Air pollution; Allergen; Asthma; Climate change; Exposome.

Publication types

Review

MeSH terms

Air Pollution, Indoor / adverse effects*
Asthma / genetics*
Asthma / metabolism*
Environmental Exposure / adverse effects*
Exposome*
Humans