[Polymorphisms in Sleep and Cognitive Function Related Genes are Associated with Vehicle Crash History in Shift Working Bus Drivers]

Zh Vyssh Nerv Deiat Im I P Pavlova. 2017 Jan;67(1):49-54.
[Article in Russian]

Abstract

Bus driving is a highly responsible profession. It requires constant engagement of attention and cog- nitive resources as well as vigilance and resistance to disruption of sleep- rhythms. There is ongoing research of genetic correlates of these individual characteristics. The aim of this study is to search for possible connections between single nucleotide polymorphisms and the history of road traffic accidents in professional bus driving. 299 professional drives working on rolling shifts with recorded history of traffic accidents took part in the study. Polymorphisms in circadian rhythm-, cognitive and emotional function-related genes were genotyped: CLOCK (rs 12649507), RORA (rs1159814), NPAS2 (rs4851377), NPSR1 (rs324981), PER3 (rs2640909), DRD3 (rs6280), SLC6A3 (rs6347), DBH(rs1611125). Significant associations for polymorphisms in CLOCK, NPSR1 and SLC6A3 with traffic crash parameters were found. We suppose that they are mediated by the difference in chronotype and sleep deprivation resistance for CLOCKand cognitive and emotional control for NPSRI and SLC6A3 polymorphisms.

MeSH terms

  • Accidents, Traffic / statistics & numerical data*
  • Adult
  • Alleles
  • Attention / physiology
  • Automobile Driving / psychology*
  • Basic Helix-Loop-Helix Transcription Factors / genetics
  • CLOCK Proteins / genetics*
  • Circadian Rhythm / genetics
  • Cognition / physiology
  • Dopamine Plasma Membrane Transport Proteins / genetics*
  • Emotions / physiology
  • Gene Expression
  • Gene Frequency
  • Humans
  • Male
  • Motor Vehicles
  • Nerve Tissue Proteins / genetics
  • Nuclear Receptor Subfamily 1, Group F, Member 1 / genetics
  • Period Circadian Proteins / genetics
  • Polymorphism, Genetic
  • Receptors, Dopamine D3 / genetics
  • Receptors, G-Protein-Coupled / genetics*
  • Russia
  • Sleep / genetics*
  • Sleep Deprivation / genetics*
  • Sleep Deprivation / physiopathology
  • Sleep Deprivation / psychology
  • Wakefulness / physiology

Substances

  • Basic Helix-Loop-Helix Transcription Factors
  • DRD3 protein, human
  • Dopamine Plasma Membrane Transport Proteins
  • NPAS2 protein, human
  • NPSR1 protein, human
  • Nerve Tissue Proteins
  • Nuclear Receptor Subfamily 1, Group F, Member 1
  • PER3 protein, human
  • Period Circadian Proteins
  • RORA protein, human
  • Receptors, Dopamine D3
  • Receptors, G-Protein-Coupled
  • SLC6A3 protein, human
  • CLOCK Proteins
  • CLOCK protein, human