Human rabies post-exposure prophylaxis relative to the disease epidemiological status

Cien Saude Colet. 2019 Jan;24(1):315-322. doi: 10.1590/1413-81232018241.32832016.


This study evaluated the prophylactic measures adopted after attacks by dogs and cats in the main city of Northwester São Paulo State, based on the technical manual for post-exposure treatment, considering the not controlled (1990-1996) and controlled (1997-2010) rabies status. A retrospective analysis was done using the data from the SINAN records (W64-CID10) between 1990 and 2010. In most cases, the accidents were mild (76.9%), and biting animals were healthy (75.4%); therefore, no treatment was needed in 53.3% of the cases. In 64.6% of cases, the prescribed PEP treatment was inappropriate. The most indicated PEP treatments consisted of vaccine and RIG (43.4%), and either three doses of mouse brain vaccine or two doses of cell culture vaccine (76.5%), during the not controlled and controlled rabies periods, respectively. The treatment was more appropriate and followed the technical recommendations during controlled rabies periods compared to not controlled (p < 0.0001) periods. However, excessive application of RIG and rabies vaccine was observed in both periods.

MeSH terms

  • Animals
  • Bites and Stings / epidemiology*
  • Bites and Stings / virology
  • Brazil / epidemiology
  • Cats
  • Child
  • Child, Preschool
  • Dogs
  • Female
  • Humans
  • Infant
  • Male
  • Mice
  • Post-Exposure Prophylaxis / statistics & numerical data*
  • Rabies / epidemiology*
  • Rabies / prevention & control
  • Rabies Vaccines / administration & dosage*
  • Retrospective Studies


  • Rabies Vaccines