Fullerene-based delivery systems

Drug Discov Today. 2019 Mar;24(3):898-905. doi: 10.1016/j.drudis.2019.01.013. Epub 2019 Jan 28.


With the development of new drugs, there have been many attempts to explore innovative delivery routes. Targeted delivery systems are a desired solution designed to overcome the deficiency of routine methods. To transform this idea into reality, a wide range of nanoparticles has been proposed and studied. These nanoparticles should interact well with biological environments and pass through cell membranes to deliver therapeutic molecules. One of the pioneer classes of carbon-based nanoparticles for targeted delivery is the fullerenes. Fullerenes have a unique structure and possess suitable properties for interaction with the cellular environment. This short review concentrates on newly developed fullerene derivatives and their potential as advanced delivery systems for pharmaceutical applications.

Publication types

  • Review

MeSH terms

  • Animals
  • Drug Delivery Systems*
  • Fullerenes* / administration & dosage
  • Fullerenes* / chemistry


  • Fullerenes