Immunomodulatory Effects of Glutathione, Garlic Derivatives, and Hydrogen Sulfide

Nutrients. 2019 Jan 30;11(2):295. doi: 10.3390/nu11020295.


Glutathione and aged garlic extract are sulfur-containing products that play important protective and regulatory roles within the immune system and in oxidative processes. Hydrogen sulfide (H₂S), an endogenous, gaseous, signaling transmitter, has also been shown to be involved in the regulation of inflammation. Recent studies have shown that sulfur-containing compounds from garlic have beneficial effects in attenuating outcomes associated with cardiovascular disease and inflammation by a mechanism that may be related to the H₂S signaling pathway. In this review, we summarize the main functions of glutathione (GSH), garlic derivatives and H₂S and their role in the immune response and impact on health and disease.

Keywords: aged garlic extract; glutathione; hydrogen sulfide; immune response; inflammation.

Publication types

  • Review

MeSH terms

  • Animals
  • Garlic*
  • Glutathione / pharmacology*
  • Humans
  • Hydrogen Sulfide / pharmacology*
  • Immunologic Factors / pharmacology*
  • Plant Extracts / pharmacology*


  • Immunologic Factors
  • Plant Extracts
  • Glutathione
  • Hydrogen Sulfide