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, 13, e00113

Biological Function and Molecular Mechanism of piRNA in Cancer


Biological Function and Molecular Mechanism of piRNA in Cancer

Ghanbar Mahmoodi Chalbatani et al. Pract Lab Med.


Cancer is the second leading cause of death globally. piRNAs, which are a novel type of identified small noncoding RNA (ncRNA), play a crucial role in cancer genomics. In recent years, a relatively large number of studies have demonstrated that several piRNA are aberrantly expressed in various kinds of cancers including gastric cancer, bladder cancer, breast cancer, colorectal cancer and Lung cancer and may probably serve as a novel therapeutic target and biomarker for cancer treatment. The present review summarized current advances in our knowledge of the roles of piRNAs in cancer.

Keywords: Cancer; Gene silencing; Noncoding RNA; PiRNA; RNAi.


Fig. 1
Fig. 1
RNA silencing by small RNAs and their partner Argonaute family proteins in Drosophila, human, and mouse RNA. The expression level of 4 PIWI protein (PIWIL3) has been a discovery in humans. The mains roles of the mature sequences, RISC formation, piRNA precursors and target genes are summarized for miRNAs, and piRNAs. The correlation between piRNA and human PIWI protein has not yet been detect. Abbreviations: dsRNA, double-stranded RNA; esiRNA, endogenous small interfering RNA(siRNA); miRNA, microRNA; nt, nucleotide; piRNA, PIWI-interacting RNA; RISC, RNA-induced silencing complex; ssRNA, single-stranded RNA.

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