Bioimpedance spectroscopy-guided fluid management in peritoneal dialysis patients with residual kidney function: A randomized controlled trial

Nephrology (Carlton). 2019 Dec;24(12):1279-1289. doi: 10.1111/nep.13571. Epub 2019 Apr 25.


Aim: Bioimpedance spectroscopy (BIS) allows volume status to be assessed objectively. This study evaluated the effect of BIS-guided fluid management on residual kidney function (RKF), volume status, and cardiovascular events in peritoneal dialysis (PD) patients.

Methods: A multicenter, prospective, randomized, controlled trial was conducted over 12 months in 2013-2017. Non-anuric PD patients (urine volume ≥ 500 mL/day) were randomized to clinical method-guided management (n = 98) or BIS-guided management (n = 103). The volume in the BIS group was controlled with BIS, with the aim of achieving the target overhydration (OH) goal of -2.0 to +2.0 L. The volume in the control group was controlled by clinical assessment alone. The groups were compared in terms of change in RKF and volume status at 12 months relative to baseline and in terms of cardiovascular event rates during a median follow-up period of 36 months.

Results: Compared with the controls, the BIS group did not show a significant improvement in change in OH, after adjustments were made for covariates (P = 0.191). The two groups did not differ in terms of delta OH, renal creatinine and urea clearance, and 24 h urine volume. The control and BIS groups also did not differ significantly in terms of change in peritoneal ultrafiltration volume, blood pressure, body weight and echocardiographic variables or in cardiovascular event rates (10.2% vs 11.3%; P = 0.953).

Conclusion: Bioimpedance spectroscopy-guided fluid management did not show an additional benefit to achieve euvolemia, and did not affect the decline in RKF in non-anuric PD patients.

Keywords: bioimpedance; cardiovascular; euvolemia; peritoneal dialysis; residual kidney function; volume.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Dielectric Spectroscopy / methods*
  • Female
  • Fluid Therapy / methods*
  • Humans
  • Kidney Failure, Chronic* / diagnosis
  • Kidney Failure, Chronic* / physiopathology
  • Kidney Failure, Chronic* / therapy
  • Kidney Function Tests / methods
  • Male
  • Middle Aged
  • Organism Hydration Status
  • Outcome Assessment, Health Care
  • Peritoneal Dialysis* / adverse effects
  • Peritoneal Dialysis* / methods
  • Water-Electrolyte Imbalance* / etiology
  • Water-Electrolyte Imbalance* / physiopathology
  • Water-Electrolyte Imbalance* / therapy