The effect of single pretreatment with salbutamol on recovery of bronchoalveolar lavage fluid in horses with suspected or confirmed severe equine asthma

J Vet Intern Med. 2019 Mar;33(2):976-980. doi: 10.1111/jvim.15359. Epub 2019 Feb 1.

Abstract

Background: Bronchoalveolar lavage (BAL) is a method for the recovery of respiratory secretion from the lower airways.

Objectives: To investigate if the administration of a single dose of a bronchodilatator in horses with a suspected or confirmed severe equine asthma could improve recovery of bronchoalveolar lavage fluid (BALF).

Animals: Twenty-eight horses with severe equine asthma.

Methods: Horses were divided into 2 groups: group "treated" was given salbutamol before endoscopic examination and BALF collection, whereas group "not treated" was not given. BAL was performed with BAL-catheter by instilling 350 mL of sterile saline. Amount of recovered fluid was recorded. Statistical analysis was performed with a two-tailed Student's t test.

Results: The average fluid recovery in the horses treated with salbutamol was 52% ± 15% (mean +/- SD), compared with 38% ± 13% for the group of horses not treated with salbutamol (P = 0.013).

Conclusions and clinical importance: Clinicians should consider administration of salbutamol before performing BAL on horses with asthma.

Keywords: albuterol; bronchi; bronchoalveolar lavage; equidae; lungs; β2-adrenergic agonist.

MeSH terms

  • Albuterol / administration & dosage*
  • Animals
  • Asthma / diagnosis
  • Asthma / drug therapy
  • Asthma / veterinary*
  • Bronchoalveolar Lavage / methods
  • Bronchoalveolar Lavage / veterinary*
  • Bronchoalveolar Lavage Fluid
  • Bronchodilator Agents / administration & dosage*
  • Endoscopy / veterinary
  • Female
  • Horse Diseases / diagnosis*
  • Horses
  • Male

Substances

  • Bronchodilator Agents
  • Albuterol