Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study

Shin Nishio; Yoshiki Mikami; Hideki Tokunaga; Nobuo Yaegashi; Toyomi Satoh; Motoaki Saito; Aikou Okamoto; Takahiro Kasamatsu; Tsutomu Miyamoto; Tanri Shiozawa; Yumiko Yoshioka; Masaki Mandai; Atsumi Kojima; Kazuhiro Takehara; Eisuke Kaneki; Hiroaki Kobayashi; Tsunehisa Kaku; Kimio Ushijima; Toshiharu Kamura

doi:10.1016/j.ygyno.2019.01.022

Analysis of gastric-type mucinous carcinoma of the uterine cervix - An aggressive tumor with a poor prognosis: A multi-institutional study

Gynecol Oncol. 2019 Apr;153(1):13-19. doi: 10.1016/j.ygyno.2019.01.022. Epub 2019 Jan 29.

Authors

Shin Nishio¹, Yoshiki Mikami², Hideki Tokunaga³, Nobuo Yaegashi³, Toyomi Satoh⁴, Motoaki Saito⁵, Aikou Okamoto⁵, Takahiro Kasamatsu⁶, Tsutomu Miyamoto⁷, Tanri Shiozawa⁷, Yumiko Yoshioka⁸, Masaki Mandai⁸, Atsumi Kojima⁹, Kazuhiro Takehara⁹, Eisuke Kaneki¹⁰, Hiroaki Kobayashi¹⁰, Tsunehisa Kaku¹⁰, Kimio Ushijima¹¹, Toshiharu Kamura¹¹

Affiliations

¹ Department of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, Japan. Electronic address: shinshin@med.kurume-u.ac.jp.
² Department of Diagnostic Pathology, Kyoto University Hospital, Kyoto, Japan.
³ Department of Obstetrics and Gynecology, Tohoku University Graduate School of Medicine, Sendai, Japan.
⁴ Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
⁵ Department of Obstetrics and Gynecology, The Jikei University School of Medicine, Tokyo, Japan.
⁶ Department of Gynecologic Oncology, National Cancer Center Hospital, Tokyo, Japan.
⁷ Department of Obstetrics and Gynecology, Shinshu University School of Medicine, Matsumoto, Japan.
⁸ Department of Gynecology and Obstetrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
⁹ Department of Gynecologic Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan.
¹⁰ Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
¹¹ Department of Obstetrics and Gynecology, Kurume University School of Medicine, Kurume, Japan.

PMID: 30709650
DOI: 10.1016/j.ygyno.2019.01.022

Abstract

Objective: Gastric-type mucinous carcinoma (GAS) is a novel variant of mucinous carcinoma of the uterine cervix. As shown in the original Japanese group description, in recent studies, GAS represents a more aggressive disease than the usual-type endocervical adenocarcinoma (UEA). Detailed clinicopathological features of this variant remain to be elucidated in a larger series of patients.

Methods: Patients were enrolled by the Gynecologic Cancer Study Group of the Japan Clinical Oncology Group after receiving the approval of each Institutional Review Board. The study population comprised of women with stage I to II endocervical adenocarcinomas who underwent surgery between 2000 and 2009. Representative slides were evaluated by central pathological review (CPR), categorized into either GAS or UEA, and correlated with clinicopathological features and outcome.

Results: Among the 393 enrolled patients with endocervical adenocarcinoma, 328 patients met the criteria for CPR and the study eligibility criteria and were included in further analysis. A total of 95 of the 328 tumors were classified as GAS. Compared with UEA, GAS was more significantly associated with bulky mass, deep stromal invasion, lymphovascular space invasion, parametrial invasion, ovarian metastasis, positive ascitic fluid cytology, pelvic lymph node metastasis, and pathological (p) T stage but was not related to the degree of histological differentiation. Disease-free survival (P < 0.0001) and overall survival (P < 0.0001) were poorer in patients with GAS than in those with UEA.

Conclusions: GAS showed aggressive behavior with ominous histopathological predictors as well as decreased survival. GAS is therefore considered a distinct entity that should be distinguished from UEA.

Clinical trial information: UMIN Clinical Trials Registry: UMIN000007987.

Keywords: Aggressive tumor; Gastric-type mucinous carcinoma; Large series; Usual-type endocervical adenocarcinoma; Uterine cervical cancer.

Publication types

Multicenter Study
Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma, Mucinous / pathology*
Adenocarcinoma, Mucinous / virology
Adult
Aged
Female
Humans
Middle Aged
Neoplasm Recurrence, Local / pathology
Neoplasm Staging
Papillomaviridae / isolation & purification
Papillomavirus Infections / diagnosis
Papillomavirus Infections / virology
Progression-Free Survival
Survival Rate
Uterine Cervical Neoplasms / pathology*
Uterine Cervical Neoplasms / virology
Young Adult

Associated data

UMIN-CTR/UMIN000007987