A mini review of bisphenol A (BPA) effects on cancer-related cellular signaling pathways

Environ Sci Pollut Res Int. 2019 Mar;26(9):8459-8467. doi: 10.1007/s11356-019-04228-9. Epub 2019 Feb 2.

Abstract

Bisphenol A (BPA) is a plasticizer used widely in many industrial products and is now well established as an endocrine-disrupting chemical (EDC). BPA readily leaches out from these products into the environment and into foodstuffs (from packaging materials) and human exposure can be considerable. Many studies have shown that BPA exposure is associated with a range of chronic human health conditions, including diabetes, cardiovascular disorders, polycystic ovarian disease, hepatotoxicity, and various types of cancer. BPA exerts its effects through deregulating cell signaling pathways associated with cell growth, proliferation, migration, invasion, and apoptosis. Previous studies on the molecular mechanisms of BPA have illustrated a variety of pathways impaired at very low exposure concentrations and that stimulate cellular responses relating to tumorigenesis both in cancer onset and progression. In this mini review, the recent advancements made through in vitro analyses are reported on for the effect of BPA on various cellular signaling pathways focusing on the signaling pathways that play a major role in carcinogenesis.

Keywords: Bisphenol A; Cancer; Signal pathway; Toxicity.

MeSH terms

  • Benzhydryl Compounds / toxicity*
  • Cell Proliferation / drug effects
  • Endocrine Disruptors / toxicity*
  • Neoplasms*
  • Phenols / toxicity*
  • Signal Transduction / drug effects

Substances

  • Benzhydryl Compounds
  • Endocrine Disruptors
  • Phenols
  • bisphenol A