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Review
. 2019 Mar;33(1):135-151.
doi: 10.1016/j.idc.2018.10.006.

Strongyloidiasis: A Neglected Tropical Disease

Alejandro Krolewiecki  1 , Thomas B Nutman  2
Affiliations
Review

Strongyloidiasis: A Neglected Tropical Disease

Alejandro Krolewiecki et al. Infect Dis Clin North Am. 2019 Mar.

Abstract

Most of the 30 to 100 million people infected with Strongyloides stercoralis have subclinical (or asymptomatic) infections. These infections are commonly chronic and longstanding. A change in immune status can increase parasite numbers, leading to hyperinfection syndrome, dissemination, and death if unrecognized. The use of corticosteroids and HTLV-1 infection are most commonly associated with the hyperinfection syndrome. Strongyloides adult parasites reside in the small intestine and induce immune responses that are like other nematodes. Definitive diagnosis of S stercoralis infection is based on stool examinations for larvae. S stercoralis remains largely neglected.

Keywords: Anthelmintic therapy; Autoinfection; Corticosteroids; Hyperinfection; Strongyloides; Strongyloidiasis.

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Conflict of interest statement

Conflicts of Interest: Neither author has any relevant conflicts of interest to declare

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