Anticatabolic Effects of Ketone Bodies in Skeletal Muscle

Trends Endocrinol Metab. 2019 Apr;30(4):227-229. doi: 10.1016/j.tem.2019.01.006. Epub 2019 Jan 31.


The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) are the subject of renewed interest given recently established pleiotropic effects regulating inflammation, oxidative stress, and gene expression. Anticatabolic effects of β-hydroxybutyrate have recently been demonstrated in human skeletal muscle under inflammatory insult, thereby expanding upon the wide-ranging therapeutic applications of nutritional ketosis.

Keywords: acetoacetate; atrophy; cachexia; inflammation; muscle protein breakdown; β-hydroxybutyrate.

Publication types

  • Review

MeSH terms

  • 3-Hydroxybutyric Acid*
  • Acetoacetates*
  • Diet, Ketogenic*
  • Humans
  • Inflammation / metabolism*
  • Ketone Bodies*
  • Ketosis / metabolism*
  • Muscle, Skeletal / metabolism*


  • Acetoacetates
  • Ketone Bodies
  • acetoacetic acid
  • 3-Hydroxybutyric Acid