From bench to bedside: Current developments and future possibilities of artificial human ovary to restore fertility

Acta Obstet Gynecol Scand. 2019 May;98(5):659-664. doi: 10.1111/aogs.13552. Epub 2019 Feb 24.


Several fertility restoration options are not feasible for some cancer patients, poor responders and patients with premature ovarian failure who have diminished ovarian reserve. To preserve and restore fertility in such patients, new strategies should be offered including artificial human ovary technology. In this mini-review, we explore from bench to bedside the current developments and future possibilities of artificial human ovary technology to restore fertility.

Keywords: artificial ovary; cancer patients; fertility restoration; oncofertility; poor responders; premature ovarian failure.

Publication types

  • Review

MeSH terms

  • Artificial Organs*
  • Female
  • Fertility Preservation* / methods
  • Fertility Preservation* / trends
  • Humans
  • Infertility, Female* / chemically induced
  • Infertility, Female* / therapy
  • Inventions
  • Ovary*
  • Primary Ovarian Insufficiency / therapy*
  • Translational Medical Research