Ascophyllum nodosum and Fucus vesiculosus on glycemic status and on endothelial damage markers in dysglicemic patients

Phytother Res. 2019 Mar;33(3):791-797. doi: 10.1002/ptr.6272. Epub 2019 Feb 3.


The aim of this study was to evaluate a nutraceutical combination containing polyphenols extracted from Ascophyllum nodosum and Fucus vesiculosus and chromium picolinate on glyemic status; secondary outcomes were considered the changes on endothelial markers. We randomized 65 dysglycemic patients to placebo or the nutraceutical agent for 6 months. We evaluated fasting plasma glucose (FPG), postprandial plasma glucose (PPG), HbA1c , fasting plasma insulin, homeostatic model assessment (HOMA) index, high sensitivity C-reactive protein (Hs-CRP), tumor necrosis factor-α (TNF-α), and adhesion molecules. At baseline and at 3 and 6 months, all patients underwent an oral glucose tolerance test. We recorded a reduction of HbA1c , FPG, PPG, and HOMA-IR compared with placebo (p < 0.05). After 6 months, 18.2% of patients retuned to a normal glycemic status in the nutraceutical group versus 0 patients in placebo group (p < 0.05); 69.7% were classified as impaired fasting glycemia and 12.1% as impaired glucose tolerance in the nutraceutical group versus 17.2% and 82.8 in placebo group (p < 0.01) for both. A reduction of Hs-CRP and TNF-α was recorded with the nutraceutical. The administration of a nutraceutical combination containing A. nodosum and F. vesiculosus can be helpful in improving insulin sensitivity and glycemic status. Larger randomized studies are required to confirm the positive effects of these agents.

Keywords: Ascophyllum nodosum; Fucus vesiculosus; dysglycemia; nutraceutical.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Ascophyllum*
  • Blood Glucose / analysis*
  • C-Reactive Protein / analysis
  • Dietary Supplements
  • Double-Blind Method
  • Dyslipidemias / blood*
  • Female
  • Fucus*
  • Humans
  • Male
  • Plant Extracts / administration & dosage*
  • Tumor Necrosis Factor-alpha / blood


  • Blood Glucose
  • Plant Extracts
  • Tumor Necrosis Factor-alpha
  • C-Reactive Protein