An Effective [FeIII(TF4DMAP)Cl] Catalyst for C-H Bond Amination with Aryl and Alkyl Azides

Yi-Dan Du; Zhen-Jiang Xu; Cong-Ying Zhou; Chi-Ming Che

doi:10.1021/acs.orglett.8b03765

An Effective [Fe^III(TF₄DMAP)Cl] Catalyst for C-H Bond Amination with Aryl and Alkyl Azides

Org Lett. 2019 Feb 15;21(4):895-899. doi: 10.1021/acs.orglett.8b03765. Epub 2019 Feb 4.

Authors

Yi-Dan Du^{1

2}, Zhen-Jiang Xu², Cong-Ying Zhou^{1

3}, Chi-Ming Che^{1

3

2}

Affiliations

¹ State Key Laboratory of Synthetic Chemistry and Department of Chemistry , The University of Hong Kong , Pokfulam Road , Hong Kong , China.
² Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis , Shanghai Institute of Organic Chemistry , 354 Feng Lin Road , Shanghai 200032 , China.
³ HKU Shenzhen Institute of Research & Innovation , Shenzhen 518053 , China.

PMID: 30715892
DOI: 10.1021/acs.orglett.8b03765

Abstract

[Fe^III(TF₄DMAP)Cl] can efficiently catalyze intermolecular sp³ C-H amination using aryl azides and intramolecular sp³ C-H amination of alkyl azides in moderate-to-high product yields. At catalyst loading down to 1 mol %, the reactions display high chemo- and regioselectivity with broad substrate scope and are effective for late-stage functionalization of complex natural/bioactive molecules.

Publication types

Research Support, Non-U.S. Gov't