Cefepime Pharmacokinetics in Critically Ill Pediatric Patients Receiving Continuous Renal Replacement Therapy

Antimicrob Agents Chemother. 2019 Mar 27;63(4):e02006-18. doi: 10.1128/AAC.02006-18. Print 2019 Apr.


This retrospective study included pediatric intensive care unit patients receiving continuous veno-venous hemodiafiltration (CVVHDF) being treated with cefepime. The free drug concentration above one time the MIC (fT>1×MIC) and four times a presumed MIC (fT>4×MIC) of 8 μg/ml were calculated. Four patients received doses ranging from 48 to 64 mg/kg of body weight every 6 to 12 h. Three patients achieved 100% fT>1×MIC, with the fourth patient achieving 98% fT>1×MIC. Therapeutic drug monitoring should be considered for critically ill patients receiving cefepime on CVVHDF.

Keywords: intensive care units; pediatrics; pharmacodynamics; pharmacokinetics; renal replacement therapy.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acute Kidney Injury / therapy
  • Anti-Bacterial Agents / pharmacokinetics*
  • Anti-Bacterial Agents / therapeutic use
  • Cefepime / pharmacokinetics*
  • Cefepime / therapeutic use
  • Child, Preschool
  • Continuous Renal Replacement Therapy*
  • Critical Illness / therapy
  • Drug Monitoring
  • Female
  • Humans
  • Infant
  • Intensive Care Units, Pediatric
  • Male
  • Retrospective Studies


  • Anti-Bacterial Agents
  • Cefepime