The genomics of major psychiatric disorders in a large pedigree from Northern Sweden

Transl Psychiatry. 2019 Feb 4;9(1):60. doi: 10.1038/s41398-019-0414-9.

Abstract

We searched for genetic causes of major psychiatric disorders (bipolar disorder, schizoaffective disorder, and schizophrenia) in a large, densely affected pedigree from Northern Sweden that originated with three pairs of founders born around 1650. We applied a systematic genomic approach to the pedigree via karyotyping (N = 9), genome-wide SNP arrays (N = 418), whole-exome sequencing (N = 26), and whole-genome sequencing (N = 10). Comprehensive analysis did not identify plausible variants of strong effect. Rather, pedigree cases had significantly higher genetic risk scores compared to pedigree and community controls.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Bipolar Disorder / epidemiology
  • Bipolar Disorder / genetics*
  • Case-Control Studies
  • Exome Sequencing / methods
  • Female
  • Genomics / methods*
  • Humans
  • Karyotyping / methods
  • Male
  • Middle Aged
  • Oligonucleotide Array Sequence Analysis / methods
  • Pedigree
  • Polymorphism, Single Nucleotide
  • Psychotic Disorders / epidemiology
  • Psychotic Disorders / genetics*
  • Schizophrenia / epidemiology
  • Schizophrenia / genetics*
  • Sweden / epidemiology
  • Whole Genome Sequencing / methods