[Ring-shaped lesions on a lung scan]

Ned Tijdschr Geneeskd. 2019 Jan 30;163:D3417.
[Article in Dutch]


A 25-year-old man was treated with pembrolizumab for a relapsed-refractory primary mediastinal large B-cell lymphoma. On an evaluation PET-CT scan multiple 'reversed halo signs' were noticed. No infectious cause was established and we diagnosed the lesions as pembrolizumab-induced pneumonitis, an immune-related adverse event.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antibodies, Monoclonal, Humanized / adverse effects*
  • Antineoplastic Agents, Immunological / adverse effects*
  • Humans
  • Lymphoma, Large B-Cell, Diffuse / drug therapy*
  • Male
  • Neoplasm Recurrence, Local / drug therapy*
  • Pneumonia / chemically induced*
  • Pneumonia / diagnostic imaging
  • Positron Emission Tomography Computed Tomography


  • Antibodies, Monoclonal, Humanized
  • Antineoplastic Agents, Immunological
  • pembrolizumab