Effect of fluoride dentifrices on white spot lesions during orthodontic treatment: A randomized trial

Angle Orthod. 2019 May;89(3):365-371. doi: 10.2319/051818-371.1. Epub 2019 Feb 5.


Objectives: To determine the effect of Clinpro 5000, Clinpro Tooth Crème, and MI-Paste Plus on the formation of white spot lesions in patients undergoing orthodontic treatment.

Materials and methods: Three prospective groups with 40 patients undergoing orthodontic treatment in each group were evaluated (total recruitment = 120 subjects). The selected product was brushed on for 2 minutes twice daily for 4 months. Subjects were reviewed for 4 months on a monthly basis. The Enamel Decalcification Index (EDI) was used to determine the number of white spot lesions per surface at each visit.

Results: 100 subjects (35 using Clinpro 5000, 32 using Clinpro Tooth Crème, and 33 using MI Paste Plus) completed the study. The data lend strong support for Clinpro 5000 providing superior protection against enamel decalcification when compared to Clinpro Crème, and mixed support when compared to MI Paste Plus.

Conclusions: The use of Clinpro 5000, Clinpro Crème, and MI paste Plus all have a reduction effect on white spot lesions when compared to studies reported previously. Clinpro 5000 has a marginally better effect than the two other test pastes. The results of this study can be used by clinicians when deciding the effectiveness of using fluoride dentifrice products to prevent white spot lesions in their orthodontic practice (ClinicalTrials.gov ID: NCT03440996).

Keywords: Dental caries; Enamel decalcification; Fluorides; Randomized controlled trial; Tooth demineralization; Toothpastes.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cariostatic Agents
  • Dental Caries* / prevention & control
  • Dentifrices* / therapeutic use
  • Fluorides
  • Humans
  • Prospective Studies
  • Tooth Movement Techniques*
  • Tooth Remineralization


  • Cariostatic Agents
  • Dentifrices
  • Fluorides

Associated data

  • ClinicalTrials.gov/NCT03440996