The spectrum of Chandler's syndrome: an often overlooked cause of unilateral glaucoma

Ophthalmology. 1978 Mar;85(3):245-51. doi: 10.1016/s0161-6420(78)35677-3.


Eleven cases of unilateral glaucoma are summarized. The typical presentations of these cases are (1) unilateral; (2) middle-aged women; (3) blurred vision; (4) corneal endothelial guttae (unilateral); (5) corneal edema; (6) stromal iris atrophy; (7) pupil abnormality; (8) peripheral anterior synechias;(9) elevated intraocular pressure; and (10) if previously diagnosed, the diagnosis is likely incorrect. Variations in these may occur. The disease can occur in men. Some patients may have nodular iris nevi. All of them represent the spectrum of Chandler's syndrome. Accurate diagnosis is important particularly in view of the optimistic prognostic implications for the fellow eye.

MeSH terms

  • Adult
  • Age Factors
  • Atrophy
  • Corneal Dystrophies, Hereditary / complications*
  • Diagnosis, Differential
  • Endothelium
  • Female
  • Functional Laterality
  • Glaucoma / etiology*
  • Humans
  • Iris / pathology
  • Male
  • Middle Aged
  • Sex Factors
  • Syndrome
  • Tissue Adhesions