Urodynamic Outcomes After Aquablation

Urology. 2019 Apr;126:165-170. doi: 10.1016/j.urology.2019.01.020. Epub 2019 Feb 2.


Objectives: To compare urodynamic outcomes between Aquablation vs transurethral resection of the prostate (TURP).

Methods: Patients were randomized 2:1 (Aquablation:TURP) in the Waterjet Ablation Therapy for Endoscopic Resection of prostate tissue study. Urodynamics were measured at baseline and 6 months.

Results: Urodynamics studies were performed in 66 of the participating subjects at baseline and 6 month follow-up. At mean baseline pDet@qmax was 71 and 73cm H20 in the Aquablation and TURP groups, respectively (P = .7031). At 6-month follow-up, pDet@qmax decreased by 35 and 34cm H20, respectively (P < .0001 compared to baseline for both arms) with no significant difference in decrease across groups (P = .8919). A large negative shift in Bladder Outlet Obstruction Index was observed, consistent with a large reduction in the proportion of subjects with obstruction at follow-up compared to baseline (79% to 22% in Aquablation and 96% to 22% in TURP).

Conclusions: In this trial, improvements after Aquablation in objective measures of bladder outlet obstruction were similar to those observed after TURP. ClinicalTrials.gov number, NCT02505919.

Publication types

  • Comparative Study
  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ablation Techniques / methods*
  • Aged
  • Aged, 80 and over
  • Double-Blind Method
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Prostatectomy / methods*
  • Prostatic Hyperplasia / complications
  • Prostatic Hyperplasia / surgery*
  • Transurethral Resection of Prostate
  • Treatment Outcome
  • Urinary Bladder Neck Obstruction / etiology
  • Urinary Bladder Neck Obstruction / surgery*
  • Urodynamics*
  • Water


  • Water

Associated data

  • ClinicalTrials.gov/NCT02505919