Respiratory sympathetic modulation is augmented in chronic kidney disease

Respir Physiol Neurobiol. 2019 Apr:262:57-66. doi: 10.1016/j.resp.2019.02.001. Epub 2019 Feb 2.


Respiratory modulation of sympathetic nerve activity (respSNA) was studied in a hypertensive rodent model of chronic kidney disease (CKD) using Lewis Polycystic Kidney (LPK) rats and Lewis controls. In adult animals under in vivo anaesthetised conditions (n = 8-10/strain), respiratory modulation of splanchnic and renal nerve activity was compared under control conditions, and during peripheral (hypoxia), and central, chemoreceptor (hypercapnia) challenge. RespSNA was increased in the LPK vs. Lewis (area under curve (AUC) splanchnic and renal: 8.7 ± 1.1 vs. 3.5 ± 0.5 and 10.6 ± 1.1 vs. 7.1 ± 0.2 μV.s, respectively, P < 0.05). Hypoxia and hypercapnia increased respSNA in both strains but the magnitude of the response was greater in LPK, particularly in response to hypoxia. In juvenile animals studied using a working heart brainstem preparation (n = 7-10/strain), increased respSNA was evident in the LPK (thoracic SNA, AUC: 0.86 ± 0.1 vs. 0.42 ± 0.1 μV.s, P < 0.05), and activation of peripheral chemoreceptors (NaCN) again drove a larger increase in respSNA in the LPK with no difference in the response to hypercapnia. Amplified respSNA occurs in CKD and may contribute to the development of hypertension.

Keywords: Chronic kidney disease; Hypertension; Peripheral chemoreceptors; Respiratory sympathetic coupling; Working heart brainstem preparation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aging / physiology
  • Animals
  • Brain Stem / physiopathology
  • Chemoreceptor Cells / physiology
  • Disease Models, Animal
  • Heart / physiopathology
  • Hypercapnia / physiopathology
  • Hypoxia / physiopathology
  • Kidney / innervation
  • Kidney / physiopathology
  • Male
  • Rats, Inbred Lew
  • Renal Insufficiency, Chronic / physiopathology*
  • Respiration*
  • Sympathetic Nervous System / physiopathology*
  • Tissue Culture Techniques