L-[Methyl-11C] Methionine-Positron-Emission Tomography (MET-PET)

Methods Mol Biol. 2019:1866:267-271. doi: 10.1007/978-1-4939-8796-2_20.


Methionine (MET) dependence is a cancer-specific metabolic abnormality that is due to MET overuse for aberrant transmethylation reactions. [11C]-MET is very useful for positron-emission tomography (PET) due to MET overuse in malignant tumors. Many benefits of MET-PET have been demonstrated. MET-PET can differentiate recurrent glioma and necrosis. [11C]-MET-PET can also predict prognosis in gliomas better than [18F]-FDG PET. [11C]-MET-PET is better than MRI for predicting survival in low-grade glioma (LGG). MET-PET has greater specificity for detecting residual tumor after surgery than MRI.

Keywords: Cancer; Hoffman effect; MET-PET; Methionine dependence; Methoinine uptake; PET imaging; Positron-emission tomography; Transmethylation; [11C]-MET.

MeSH terms

  • Cell Line, Tumor
  • Fluorodeoxyglucose F18 / chemistry
  • Humans
  • Methionine / analogs & derivatives*
  • Methionine / chemistry
  • Neoplasms / diagnostic imaging
  • Positron-Emission Tomography*


  • Fluorodeoxyglucose F18
  • Methionine
  • methionine methyl ester