Cardiovascular disease (CVD) is known as the number one cause of death worldwide. It is associated with huge health care costs and loss of productivity in the population. Poor diet is an important risk factor in CVD. Diet rich in polyunsaturated fatty acids, such as virgin coconut oil (VCO), has been associated with a reduced risk of CVD. This systematic review focused on studies that reported the association between VCO and the biochemical measurements associated with CVD. These studies conclude that VCO shows promising effects in improving the biochemical derangements associated with CVD, thus lowering the CVD risk. However, most of these studies were performed in animals with very limited data from human. Future investigations are needed to examine the health benefits of VCO in human intervention studies.