A Case of Aplastic Anemia Associated With Long-Term Metronidazole Use

J Pharm Pract. 2020 Aug;33(4):540-542. doi: 10.1177/0897190019825584. Epub 2019 Feb 6.

Abstract

Metronidazole is a nitroimidazole antibacterial agent that is highly effective for the treatment of protozoal and anaerobic infections. Metronidazole is known to cause hematologic adverse effects, including a reversible mild neutropenia; in rare circumstances, thrombocytopenia has been associated with metronidazole treatment. We present a case of aplastic anemia related to the extended use of metronidazole.

Keywords: aplastic anemia; hematologic dyscrasia; metronidazole; neutropenia.

Publication types

  • Case Reports

MeSH terms

  • Anemia, Aplastic* / chemically induced
  • Anemia, Aplastic* / diagnosis
  • Anti-Bacterial Agents / adverse effects
  • Humans
  • Metronidazole / adverse effects
  • Thrombocytopenia

Substances

  • Anti-Bacterial Agents
  • Metronidazole