The use of monoclonal antibodies for clinical applications has increased dramatically in the past few years. Monoclonal antibodies are used for the detection of bacterial and viral infections, determination of the presence and stage of cancer, and as diagnostics for the detection and quantitation of low molecular weight compounds of clinical and biochemical interest. The latter application has also taken place through the development of monoclonal antibody-based sensors. The ease of monoclonal antibody synthesis and their high degree of antigen specificity has made monoclonal antibodies ideal for the aforementioned clinical applications. Recent US patents and scientific literature on clinical applications of monoclonal antibodies are surveyed. Patent abstracts are summarized individually and a list of literature references are given.