Ovariectomy/Orchiectomy in Rodents

Methods Mol Biol. 2019:1914:261-267. doi: 10.1007/978-1-4939-8997-3_13.

Abstract

This chapter describes the surgical procedures for ovariectomy and orchiectomy in mice and rats. In addition to providing technical details of the surgical techniques, details of anesthesia options and pre-, peri-, and postoperative care are also included.

Keywords: Androgen; Bone loss; Mouse; Oestrogen; Orchiectomy; Ovariectomy; Rat; Resorption; Rodents; Surgery.

MeSH terms

  • Animals
  • Bone Resorption / metabolism
  • Bone Resorption / pathology*
  • Disease Models, Animal*
  • Estrogens / metabolism
  • Female
  • Humans
  • Male
  • Mice
  • Orchiectomy / instrumentation
  • Orchiectomy / methods
  • Ovariectomy / instrumentation
  • Ovariectomy / methods
  • Ovary / metabolism
  • Ovary / surgery
  • Rats
  • Testis / metabolism
  • Testis / surgery

Substances

  • Estrogens