Bio-Organometallic Derivatives of Antibacterial Drugs

Chemistry. 2019 May 28;25(30):7232-7242. doi: 10.1002/chem.201805985. Epub 2019 Mar 18.


Overuse and misuse of antibacterial drugs has resulted in bacteria resistance and in an increase in mortality rates due to bacterial infections. Therefore, there is an imperative necessity of new antibacterial drugs. Bio-organometallic derivatives of antibacterial agents offer an opportunity to discover new active antibacterial drugs. These compounds are well-characterized products and, in several examples, their antibacterial activities have been studied. Both inhibition of the antibacterial activity and strong increase in the antibiotic activity of the parent drug have been found. The synthesis of the main classes of bio-organometallic derivatives of these drugs, as well as examples of the use of structure-activity relation (SAR) studies to increase the activity and to understand the mode of action of bio-organometallic antimicrobial peptides (BOAMPs) and platensimicyn bio-organometallic mimics is presented in this article.

Keywords: antibiotics; bio-organometallic antibacterial peptides; lactams; metallacycles; platensimycin mimics; silver.

Publication types

  • Review

MeSH terms

  • Adamantane / chemical synthesis
  • Adamantane / pharmacology
  • Aminobenzoates / chemical synthesis
  • Aminobenzoates / pharmacology
  • Anilides / chemical synthesis
  • Anilides / pharmacology
  • Anti-Bacterial Agents / chemical synthesis*
  • Anti-Bacterial Agents / pharmacology
  • Antimicrobial Cationic Peptides / chemical synthesis
  • Antimicrobial Cationic Peptides / pharmacology
  • Biocompatible Materials / chemical synthesis*
  • Biocompatible Materials / pharmacology
  • Biomimetic Materials / chemical synthesis
  • Biomimetic Materials / pharmacology
  • Humans
  • Metals / chemistry
  • Molecular Structure
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / pharmacology
  • Structure-Activity Relationship


  • Aminobenzoates
  • Anilides
  • Anti-Bacterial Agents
  • Antimicrobial Cationic Peptides
  • Biocompatible Materials
  • Metals
  • Organometallic Compounds
  • Adamantane
  • platensimycin