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. 2019 Feb 15;21(4):1187-1190.
doi: 10.1021/acs.orglett.9b00135. Epub 2019 Feb 7.

Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta

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Minnamide A, a Linear Lipopeptide from the Marine Cyanobacterium Okeania hirsuta

Shimpei Sumimoto et al. Org Lett. .

Abstract

Minnamide A is a lipopeptide with a unique repeating structure consisting of hydroxy and proposed β-branched methyl groups. The absolute configuration of minnamide A was determined by a combination of chemical degradation, chiral HPLC analyses, and synthetic methods. Minnamide A showed growth-inhibitory activity toward HeLa cells with an IC50 value of 0.17 μM and rapidly induced cell death at a concentration of 2 μM. Minnamide A induced the copper-mediated accumulation of reactive oxygen species.

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