Molecular effects of dietary fatty acids on brain insulin action and mitochondrial function

Chantal Chudoba; Kristina Wardelmann; André Kleinridders

doi:10.1515/hsz-2018-0477

Molecular effects of dietary fatty acids on brain insulin action and mitochondrial function

Biol Chem. 2019 Feb 7;400(8):991-1003. doi: 10.1515/hsz-2018-0477. Print 2019 Jul 26.

Authors

Chantal Chudoba^{1

2}, Kristina Wardelmann^{1

2}, André Kleinridders^{1

2}

Affiliations

¹ Central Regulation of Metabolism, German Institute of Human Nutrition (DIfE), Arthur-Scheunert-Allee 114-116, D-14558 Nuthetal, Germany.
² German Center for Diabetes Research (DZD), Ingolstädter Landstraße 1, D-85764 Neuherberg, Germany.

PMID: 30730834
DOI: 10.1515/hsz-2018-0477

Abstract

The prevalence of obesity and its co-morbidities such as insulin resistance and type 2 diabetes are tightly linked to increased ingestion of palatable fat enriched food. Thus, it seems intuitive that the brain senses elevated amounts of fatty acids (FAs) and affects adaptive metabolic response, which is connected to mitochondrial function and insulin signaling. This review will address the effect of dietary FAs on brain insulin and mitochondrial function with a special emphasis on the impact of different FAs on brain function and metabolism.

Keywords: brain; fatty acids; insulin signaling; ketone bodies; mitochondrial function; neuronal health.

Publication types

Review