Fat cells gobbling up norepinephrine?

PLoS Biol. 2019 Feb 7;17(2):e3000138. doi: 10.1371/journal.pbio.3000138. eCollection 2019 Feb.


The sympathetic nervous system (SNS) controls key aspects of adipose tissue (AT) function through the release of norepinephrine (NE) and beta adrenergic signaling. Sympathetic tone is determined by NE release but also by the rate of extracellular NE clearance that historically has been believed to occur solely through solute carrier family 6 member 2 (SLC6A2) expressed on sympathetic neurons. Song and colleagues show that adipocytes can also clear NE through organic cation transporter 3 (Oct3). This contributes to our understanding of how adrenergic signaling is controlled in AT and also emphasizes the need to develop better methods to assess adrenergic signaling in vivo.

Publication types

  • Comment

MeSH terms

  • Adipocytes
  • Adipose Tissue, White
  • Catecholamines*
  • Cations
  • Norepinephrine*


  • Catecholamines
  • Cations
  • Norepinephrine

Grants and funding

The authors received no specific funding for this work.