Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Randomized Controlled Trial
, 14 (2), e0211850
eCollection

Associations Between Adverse Childhood Experiences and Health Outcomes in Adults Aged 18-59 Years

Affiliations
Randomized Controlled Trial

Associations Between Adverse Childhood Experiences and Health Outcomes in Adults Aged 18-59 Years

Xuening Chang et al. PLoS One.

Abstract

Background: Adverse childhood experiences (ACEs) have been associated with poor health status later in life. The objective of the present study was to examine the relationship between ACEs and health-related behaviors, chronic diseases, and mental health in adults.

Methods: A cross-sectional study was performed with 1501 residents of Macheng, China. The ACE International Questionnaire (ACE-IQ) was used to assess ACEs, including psychological, physical, and sexual forms of abuse, as well as household dysfunction. The main outcome variables were lifetime drinking status, lifetime smoking status, chronic diseases, depression, and posttraumatic stress disorder. Multiple logistic regression models were used to examine the associations between overall ACE score and individual ACE component scores and risk behaviors/comorbidities in adulthood after controlling for potential confounders.

Results: A total of 66.2% of participants reported at least one ACE, and 5.93% reported four or more ACEs. Increased ACE scores were associated with increased risks of drinking (adjusted odds ratio [AOR] = 1.09, 95% confidence intervals [CI]: 1.00-1.09), chronic disease (AOR = 1.17, 95% CI: 1.06-1.28), depression (AOR = 1.37, 95% CI: 1.27-1.48), and posttraumatic stress disorder (AOR = 1.32, 95% CI: 1.23-1.42) in adulthood. After adjusting for confounding factors, the individual ACE components had different impacts on risk behavior and health, particularly on poor mental health outcomes in adulthood.

Conclusions: ACEs during childhood were significantly associated with risk behaviors and poor health outcomes in adulthood, and different ACE components had different long-term effects on health outcomes in adulthood.

Conflict of interest statement

The authors have declared that no competing interests exist.

Similar articles

See all similar articles

Cited by 2 PubMed Central articles

References

    1. Felitti VJ, Anda RF, Nordenberg D, Williamson DF, Spitz AM, Edwards V, et al. Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults. The Adverse Childhood Experiences (ACE) Study. American journal of preventive medicine. 1998;14(4):245–58. Epub 1998/06/23. . - PubMed
    1. Holman DM, Ports KA, Buchanan ND, Hawkins NA, Merrick MT, Metzler M, et al. The Association Between Adverse Childhood Experiences and Risk of Cancer in Adulthood: A Systematic Review of the Literature. Pediatrics. 2016;138(Suppl 1):S81–S91. 10.1542/peds.2015-4268L . - DOI - PMC - PubMed
    1. Campbell JA, Walker RJ, Egede LE. Associations Between Adverse Childhood Experiences, High-Risk Behaviors, and Morbidity in Adulthood. American journal of preventive medicine. 2016;50(3):344–52. Epub 2015/10/18. 10.1016/j.amepre.2015.07.022 ; PubMed Central PMCID: PMCPmc4762720. - DOI - PMC - PubMed
    1. Kelly-Irving M, Lepage B, Dedieu D, Bartley M, Blane D, Grosclaude P, et al. Adverse childhood experiences and premature all-cause mortality. Eur J Epidemiol. 2013;28(9):721–34. 10.1007/s10654-013-9832-9 - DOI - PMC - PubMed
    1. Brown DW, Anda RF, Tiemeier H, Felitti VJ, Edwards VJ, Croft JB, et al. Adverse childhood experiences and the risk of premature mortality. American journal of preventive medicine. 2009;37(5):389–96. 10.1016/j.amepre.2009.06.021 . - DOI - PubMed

Publication types

MeSH terms

Grant support

This work was funded by No. 2013CFB125, http://www.hbstd.gov.cn/. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Feedback