A methodology for numerically analysing the hepatic artery haemodynamics during B-TACE: a proof of concept

Comput Methods Biomech Biomed Engin. 2019 Apr;22(5):518-532. doi: 10.1080/10255842.2019.1567720. Epub 2019 Feb 7.


Balloon-occluded transarterial chemoembolisation (B-TACE) is an intraarterial transcatheter treatment for liver cancer. In B-TACE, an artery-occluding microballoon catheter occludes an artery and promotes collateral circulation for drug delivery to tumours. This paper presents a methodology for analysing the haemodynamics during B-TACE, by combining zero-dimensional and three-dimensional modelling tools. As a proof of concept, we apply the methodology to a patient-specific hepatic artery geometry and analyse two catheter locations. Results show that the blood flow redistribution can be predicted in this proof-of-concept study, suggesting that this approach could potentially be used to optimise catheter location.

Keywords: 0D modelling; 3D modelling; B-TACE; Liver cancer; computational fluid dynamics; haemodynamics.

MeSH terms

  • Chemoembolization, Therapeutic*
  • Computer Simulation
  • Hemodynamics / physiology*
  • Hepatic Artery / physiopathology*
  • Humans
  • Imaging, Three-Dimensional
  • Models, Biological
  • Numerical Analysis, Computer-Assisted*