Clinical Practice Guideline for Emergency Department Procedural Sedation With Propofol: 2018 Update

Ann Emerg Med. 2019 May;73(5):470-480. doi: 10.1016/j.annemergmed.2018.12.012. Epub 2019 Feb 4.


We update an evidence-based clinical practice guideline for the administration of propofol for emergency department procedural sedation. Both the unique considerations of using this drug in the pediatric population and the substantial new research warrant revision of the 2007 advisory. We discuss the indications, contraindications, personnel requirements, monitoring, dosing, coadministered medications, and adverse events for propofol sedation.

MeSH terms

  • Anesthetics, Intravenous / administration & dosage*
  • Anesthetics, Intravenous / adverse effects
  • Drug Dosage Calculations
  • Drug Therapy, Combination
  • Emergency Service, Hospital
  • Evidence-Based Medicine
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Practice Guidelines as Topic
  • Propofol / administration & dosage*
  • Propofol / adverse effects


  • Anesthetics, Intravenous
  • Propofol