Do CO 2 and oxidative stress induce cancer?: a brief study about the evaluation of PON 1, CAT, CA and XO enzyme levels on head and neck cancer patients

J Enzyme Inhib Med Chem. 2019 Dec;34(1):459-464. doi: 10.1080/14756366.2018.1555157.


Head and neck cancer (HNC) is one of the most common malignancies in the world. HNC is a group of cancers that starts in the mouth, nose, throat, larynx, sinuses, or salivary glands. According to this section of the body parts; induction of cancer can be associated with CO2 and oxidative stress. The aim of this study is to assess the activities of carbonic anhydrase (CA), catalase (CAT), paraoxonase1 (PON1), and xanthine oxidase (XO) activities in 89 HNC patients and 115 healthy volunteers. Paraoxonase1 activity was found lower in HNC cancer patients. There is no statistically significant difference between patients and controls for catalase, carbonic anhydrase, and xanthine oxidase enzyme levels. According to this results, paraoxonase1 levels could be a candidate as an oxidative marker in HNC patients, but further studies are needed to investigate the other type of cancer related PON1 and the other enzyme levels.

Keywords: Carbonic anhydrase; catalase; head and neck cancer; paraoxonase; xanthine oxidase.

MeSH terms

  • Aryldialkylphosphatase / blood
  • Aryldialkylphosphatase / metabolism*
  • Biomarkers, Tumor / blood
  • Biomarkers, Tumor / metabolism*
  • Carbon Dioxide / blood
  • Carbon Dioxide / metabolism*
  • Carbonic Anhydrases / blood
  • Carbonic Anhydrases / metabolism*
  • Catalase / blood
  • Catalase / metabolism*
  • Female
  • Head and Neck Neoplasms / blood
  • Head and Neck Neoplasms / metabolism*
  • Healthy Volunteers
  • Humans
  • Male
  • Middle Aged
  • Oxidative Stress
  • Xanthine Oxidase / blood
  • Xanthine Oxidase / metabolism*


  • Biomarkers, Tumor
  • Carbon Dioxide
  • CAT protein, human
  • Catalase
  • Xanthine Oxidase
  • Aryldialkylphosphatase
  • PON1 protein, human
  • Carbonic Anhydrases