Metabolic plasticity meets gene regulation

doi:10.1073/pnas.1900169116

Comment

. 2019 Feb 26;116(9):3370-3372.

doi: 10.1073/pnas.1900169116. Epub 2019 Feb 8.

Metabolic plasticity meets gene regulation

B Bishal Paudel^{1

2}, Vito Quaranta^{3

2}

Affiliations

¹ Department of Biochemistry, Vanderbilt University, Nashville, TN, 37232.
² Quantitative Systems Biology Center, Vanderbilt University, Nashville, TN, 37232.
³ Department of Biochemistry, Vanderbilt University, Nashville, TN, 37232; vito.quaranta@vanderbilt.edu.

PMID: 30737291
PMCID: PMC6397587
DOI: 10.1073/pnas.1900169116

Free PMC article

Comment

Metabolic plasticity meets gene regulation

B Bishal Paudel et al. Proc Natl Acad Sci U S A. 2019.

Free PMC article

. 2019 Feb 26;116(9):3370-3372.

doi: 10.1073/pnas.1900169116. Epub 2019 Feb 8.

Authors

B Bishal Paudel^{1

2}, Vito Quaranta^{3

2}

Affiliations

¹ Department of Biochemistry, Vanderbilt University, Nashville, TN, 37232.
² Quantitative Systems Biology Center, Vanderbilt University, Nashville, TN, 37232.
³ Department of Biochemistry, Vanderbilt University, Nashville, TN, 37232; vito.quaranta@vanderbilt.edu.

PMID: 30737291
PMCID: PMC6397587
DOI: 10.1073/pnas.1900169116

No abstract available

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Fig. 1.**
Metabolic landscape of normal and cancer cells. (A) Transcriptomics and metabolomics (end-product metabolites) analyses show the coexistence of three distinct metabolic phenotypes: glycolytic (W), oxidative (O), and high-high, or hybrid (W/O) states in cancer cells, whereas normal cells exhibit only two states. (B) External perturbations lead to metabolic reprogramming in cancer cells. (*Left*) glycolytic inhibition increases the O and W/O states. (*Middle*) OXPHOS inhibition increases the W and W/O states. (*Right*) Stable HIF-1 or low mitochondrial ROS (mtROS) induces the metabolic low-low phenotype.

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Comment on

Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways.
Jia D, Lu M, Jung KH, Park JH, Yu L, Onuchic JN, Kaipparettu BA, Levine H. Jia D, et al. Proc Natl Acad Sci U S A. 2019 Feb 26;116(9):3909-3918. doi: 10.1073/pnas.1816391116. Epub 2019 Feb 7. Proc Natl Acad Sci U S A. 2019. PMID: 30733294 Free PMC article.

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References

1. Warburg O. The metabolism of carcinoma cells. J Cancer Res. 1925;9:148–163.
1. Som P, et al. A fluorinated glucose analog, 2-fluoro-2-deoxy-D-glucose (F-18): nontoxic tracer for rapid tumor detection. J Nucl Med. 1980;21:670–675. - PubMed
1. Dang CV. Links between metabolism and cancer. Genes Dev. 2012;26:877–890. - PMC - PubMed
1. DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 2008;7:11–20. - PubMed
1. Ward PS, Thompson CB. Metabolic reprogramming: A cancer hallmark even warburg did not anticipate. Cancer Cell. 2012;21:297–308. - PMC - PubMed

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[1] Warburg O. The metabolism of carcinoma cells. J Cancer Res. 1925;9:148–163.

[2] Warburg O. The metabolism of carcinoma cells. J Cancer Res. 1925;9:148–163.

[3] Som P, et al. A fluorinated glucose analog, 2-fluoro-2-deoxy-D-glucose (F-18): nontoxic tracer for rapid tumor detection. J Nucl Med. 1980;21:670–675. - PubMed

[4] Som P, et al. A fluorinated glucose analog, 2-fluoro-2-deoxy-D-glucose (F-18): nontoxic tracer for rapid tumor detection. J Nucl Med. 1980;21:670–675. - PubMed

[5] Dang CV. Links between metabolism and cancer. Genes Dev. 2012;26:877–890. - PMC - PubMed

[6] Dang CV. Links between metabolism and cancer. Genes Dev. 2012;26:877–890. - PMC - PubMed

[7] DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 2008;7:11–20. - PubMed

[8] DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 2008;7:11–20. - PubMed

[9] Ward PS, Thompson CB. Metabolic reprogramming: A cancer hallmark even warburg did not anticipate. Cancer Cell. 2012;21:297–308. - PMC - PubMed

[10] Ward PS, Thompson CB. Metabolic reprogramming: A cancer hallmark even warburg did not anticipate. Cancer Cell. 2012;21:297–308. - PMC - PubMed

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Metabolic plasticity meets gene regulation

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Metabolic plasticity meets gene regulation

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