Genome-wide association study of monoclonal gammopathy of unknown significance (MGUS): comparison with multiple myeloma

Hauke Thomsen; Subhayan Chattopadhyay; Niels Weinhold; Pavel Vodicka; Ludmila Vodickova; Per Hoffmann; Markus M Nöthen; Karl-Heinz Jöckel; Christian Langer; Roman Hajek; Göran Hallmans; Ulrika Pettersson-Kymmer; Claes Ohlsson; Florentin Späth; Richard Houlston; Hartmut Goldschmidt; Kari Hemminki; Asta Försti

doi:10.1038/s41375-019-0396-x

Genome-wide association study of monoclonal gammopathy of unknown significance (MGUS): comparison with multiple myeloma

Leukemia. 2019 Jul;33(7):1817-1821. doi: 10.1038/s41375-019-0396-x. Epub 2019 Feb 8.

Authors

Hauke Thomsen¹, Subhayan Chattopadhyay¹, Niels Weinhold^{2

3}, Pavel Vodicka^{4

5

6}, Ludmila Vodickova^{4

5

6}, Per Hoffmann^{7

8}, Markus M Nöthen^{7

9}, Karl-Heinz Jöckel¹⁰, Christian Langer¹¹, Roman Hajek¹², Göran Hallmans¹³, Ulrika Pettersson-Kymmer¹⁴, Claes Ohlsson¹⁵, Florentin Späth¹⁶, Richard Houlston^{17

18}, Hartmut Goldschmidt^{2

19}, Kari Hemminki¹, Asta Försti²⁰

Affiliations

¹ Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany.
² Department of Internal Medicine V, University of Heidelberg, Heidelberg, Germany.
³ Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
⁴ Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnska 1083, 142 00, Prague, Czech Republic.
⁵ Institute of Biology and Medical Genetics, 1st Medical Faculty, Charles University, Albertov 4, 128 00, Prague, Czech Republic.
⁶ Faculty of Medicine and Biomedical Center in Pilsen, Charles University in Prague, 30605, Pilsen, Czech Republic.
⁷ Institute of Human Genetics, University of Bonn, Bonn, Germany.
⁸ Department of Biomedicine, University of Basel, Basel, Switzerland.
⁹ Department of Genomics, Life & Brain Research Center, University of Bonn, Bonn, Germany.
¹⁰ Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
¹¹ Department of Internal Medicine III, University of Ulm, Ulm, Germany.
¹² Department of Hematooncology, University Hospital Ostrava, 17. listopadu 1790, 708 52, Ostrava, Czech Republic.
¹³ Department of Medical Biosciences/Pathology, University of Umea, Umea, Sweden.
¹⁴ Clinical Pharmacology, Department of Pharmacology and Clinical Neuroscience, Umea University, Umea, Sweden.
¹⁵ Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
¹⁶ Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden.
¹⁷ Division of Genetics and Epidemiology, The Institute of Cancer Research, London, UK.
¹⁸ Division of Molecular Pathology, The Institute of Cancer Research, London, UK.
¹⁹ National Centre of Tumor Diseases, Heidelberg, Germany.
²⁰ Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, D-69120, Heidelberg, Germany. a.foersti@dkfz.de.

PMID: 30737484
DOI: 10.1038/s41375-019-0396-x

No abstract available

Publication types

Comparative Study
Letter
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor / genetics*
Genome-Wide Association Study*
Humans
Monoclonal Gammopathy of Undetermined Significance / genetics*
Monoclonal Gammopathy of Undetermined Significance / pathology
Multiple Myeloma / genetics*
Multiple Myeloma / pathology
Mutation*
Prognosis

Substances

Biomarkers, Tumor