Bone mass development is sensitive to insulin resistance in adolescent boys

Maria Sode Rønne; Malene Heidemann; Louise Lylloff; Anders J Schou; Jakob Tarp; Anna Bugge; Jens Ole Laursen; Niklas Rye Jørgensen; Steffen Husby; Niels Wedderkopp; Christian Mølgaard

doi:10.1016/j.bone.2019.02.005

Bone mass development is sensitive to insulin resistance in adolescent boys

Bone. 2019 May:122:1-7. doi: 10.1016/j.bone.2019.02.005. Epub 2019 Feb 7.

Authors

Affiliations

¹ Hans Christian Andersen Children's Hospital, Odense University Hospital, Kløvervænget 23C, 5000 Odense C, Denmark; Department of Clinical Research, University of Southern Denmark, Winsløwparken 19, 3, 5000 Odense C, Denmark. Electronic address: mariasr@dadlnet.dk.
² Hans Christian Andersen Children's Hospital, Odense University Hospital, Kløvervænget 23C, 5000 Odense C, Denmark.
³ Department of Clinical Biochemistry, Rigshospitalet, Glostrup, Valdemar Hansens Vej 1-23, 2600 Glostrup, Denmark; Department of Clinical Biochemistry, Hospital Unit West, Gl. Landevej 61, 7400 Herning, Denmark.
⁴ Research Unit for Exercise Epidemiology, Research in Childhood Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark.
⁵ Research Unit for Exercise Epidemiology, Research in Childhood Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark; Department of Physiotherapy and Occupational Therapy, University College Copenhagen, Sigurdsgade 26, 2200 København N, Denmark.
⁶ Emergency Department, Hospital of South Jutland, Kresten Philipsens Vej 15, 6200 Aabenraa, Denmark.
⁷ Department of Clinical Biochemistry, Rigshospitalet, Glostrup, Valdemar Hansens Vej 1-23, 2600 Glostrup, Denmark; OPEN, Odense Patient data Explorative Network, Department of Clinical Research, University of Southern Denmark, J.B.Winsløws Vej 9 A, 3, 5000 Odense C, Denmark.
⁸ Hans Christian Andersen Children's Hospital, Odense University Hospital, Kløvervænget 23C, 5000 Odense C, Denmark; Department of Clinical Research, University of Southern Denmark, Winsløwparken 19, 3, 5000 Odense C, Denmark.
⁹ Research Unit for Exercise Epidemiology, Research in Childhood Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark; Department of Orthopaedics, Hospital of Southwestern Denmark, Finsensgade 34, 6700 Esbjerg, Denmark.
¹⁰ Hans Christian Andersen Children's Hospital, Odense University Hospital, Kløvervænget 23C, 5000 Odense C, Denmark; Department of Clinical Research, University of Southern Denmark, Winsløwparken 19, 3, 5000 Odense C, Denmark; Department of Nutrition, Exercise and Sports, University of Copenhagen, Nørre Allé 51, 2200 København N, Denmark.

PMID: 30738213
DOI: 10.1016/j.bone.2019.02.005

Abstract

Purpose: Insulin resistance may exert a negative influence on bone mass in childhood and adolescence. The objective was to assess the association between insulin resistance and total body less head (TBLH) bone mineral content (BMC) and to investigate whether body composition, physical activity or osteocalcin levels may influence this association.

Methods: A longitudinal study with follow-up over more than 6 years was performed and included 562 apparently healthy participants with a mean age of 9.6 years at baseline. Participants underwent DXA scanning at baseline. At the two follow-ups, participants had performed another DXA scanning, had blood samples taken for fasting insulin, glucose and osteocalcin and had physical activity measured with an accelerometer. HOMA-IR was calculated as an index of insulin resistance.

Results: HOMA-IR was negatively associated with TBLH BMC in boys at follow-ups (β = -31.4, p < 0.001) after adjustment for maturity, height, bone area, and baseline level of TBLH BMC. The negative association remained almost unchanged after further adjustments for body composition and physical activity. No association between HOMA-IR and TBLH BMC was found in girls.

Conclusion: Insulin resistance may be detrimental for bone development through puberty in boys independent of body composition and the level of physical activity.

Keywords: Bone mass; Dual energy X-ray absorptiometry; HOMA-IR; Physical activity; Puberty.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Bone Density
Bone and Bones / pathology*
Child
Female
Humans
Insulin Resistance*
Male
Organ Size