Myosin Heavy Chain 9: Oncogene or Tumor Suppressor Gene?

Med Sci Monit. 2019 Jan 31:25:888-892. doi: 10.12659/MSM.912320.


MYH9 was first discovered due to thrombocytopenia caused by MYH9 mutation-related abnormalities. In recent years, researchers have increasingly found that MYH9 plays an important role in cancer as a cytokine involved in cytoskeletal reorganization, cellular pseudopodia formation, and migration. MYH9 is closely related to the progress and poor prognosis of most solid tumors, and it is now accepted that MYH9 is a suppressor gene and plays an important role on the re-Rho pathway. Recent research has been limited to the study of tissues. However, it would be more direct and informative to be able to use hematology to assess tumor prognosis and changes in MYH9 levels and NMMHC-IIA. This article summarizes recent research on MYH9 and provides a reference for future clinical research.

Publication types

  • Review

MeSH terms

  • Blood Platelets
  • Genes, Tumor Suppressor / physiology
  • Humans
  • Molecular Motor Proteins / genetics
  • Molecular Motor Proteins / metabolism*
  • Molecular Motor Proteins / physiology*
  • Mutation
  • Myosin Heavy Chains / genetics
  • Myosin Heavy Chains / metabolism*
  • Myosin Heavy Chains / physiology*
  • Oncogenes / immunology
  • Oncogenes / physiology
  • Thrombocytopenia


  • MYH9 protein, human
  • Molecular Motor Proteins
  • Myosin Heavy Chains