Estrogen Receptor Beta Expression Correlates With Proliferation in Desmoid Tumors

J Surg Oncol. 2019 Jun;119(7):873-879. doi: 10.1002/jso.25407. Epub 2019 Feb 11.


Background and objectives: Estrogen receptor signaling and cyclin D1 have a major role in tumor cell proliferation in breast cancer. Desmoid tumors are rare neoplasms that may respond to endocrine treatment. The present study aimed to investigate the expression levels and the clinical relevance of estrogen receptor beta (ERβ) and cyclin D1 in desmoid tumors.

Methods: This study consists of 83 patients with a surgically treated desmoid tumor. ERβ and cyclin D1 expression was examined by immunohistochemistry in tissue microarrays. Cyclin A and Ki67 were studied in our previous work.

Results: Median ERβ expression was 10.8%. ERβ expression correlated with expression of the proliferation antigens Ki67 (rp = 0.35, P = 0.003), cyclin D1 (rp = 0.34, P = 0.004), and cyclin A (rp = 0.34, P = 0.004). ERβ immunoexpression showed a trend towards predictive impact for recurrence as a continuous variable. Further explorative analysis indicated that very high ERβ expression was related to high risk of relapse (hazard ratio [HR] 2.6; P = 0.02). Median cyclin D1 expression was 15.6%. High cyclin D1 expression was associated with high Ki67 and cyclin A expression. Cyclin D1 was not associated with time to recurrence.

Conclusions: ERβ and cyclin D1 immunopositivity correlated with high proliferation in desmoid tumors. High ERβ expression might be predictive for postoperative recurrence.

Keywords: aggressive fibromatosis; biomarkers; cyclins; immunohistochemistry; steroid receptors.

MeSH terms

  • Adult
  • Biomarkers, Tumor / biosynthesis
  • Cell Growth Processes / physiology
  • Cyclin D1 / biosynthesis
  • Estrogen Receptor beta / biosynthesis*
  • Female
  • Fibromatosis, Aggressive / metabolism*
  • Fibromatosis, Aggressive / pathology*
  • Humans
  • Immunohistochemistry
  • Male
  • Neoplasm Recurrence, Local / metabolism
  • Neoplasm Recurrence, Local / pathology
  • Predictive Value of Tests
  • Retrospective Studies
  • Tissue Array Analysis


  • Biomarkers, Tumor
  • CCND1 protein, human
  • ESR2 protein, human
  • Estrogen Receptor beta
  • Cyclin D1