Formulations of Curcumin Nanoparticles for Brain Diseases

Biomolecules. 2019 Feb 8;9(2):56. doi: 10.3390/biom9020056.


Curcumin is a polyphenol that is obtained from Curcuma longa and used in various areas, such as food and textiles. Curcumin has important anti-inflammatory and antioxidant properties that allow it to be applied as treatment for several emerging pathologies. Remarkably, there are an elevated number of publications deriving from the terms "curcumin" and "curcumin brain diseases", which highlights the increasing impact of this polyphenol and the high number of study groups investigating their therapeutic actions. However, its lack of solubility in aqueous media, as well as its poor bioavailability in biological systems, represent limiting factors for its successful application. In this review article, the analysis of its chemical composition and the pivotal mechanisms for brain applications are addressed in a global manner. Furthermore, we emphasize the use of nanoparticles with curcumin and the benefits that have been reached as an example of the extensive advances in this area of health.

Keywords: Alzheimer’s disease; Parkinson’s disease; brain diseases; curcumin; inflammation; nanoparticles; protein aggregation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / chemistry
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use*
  • Brain Diseases / drug therapy*
  • Curcuma / chemistry
  • Curcumin / chemistry
  • Curcumin / therapeutic use*
  • Humans
  • Molecular Structure
  • Nanoparticles / chemistry*
  • Temperature


  • Anti-Inflammatory Agents, Non-Steroidal
  • Curcumin