In a recent study, a neuroanatomical-based age prediction model observed neuromaturational deviance among clinical high-risk individuals who developed psychosis. Here we aimed to investigate whether incorporating "brain age gap" (discrepancy between neuroanatomical-based predicted age and chronological age) to the North American Prodromal Longitudinal Study risk calculator would enhance prediction of psychosis conversion. The effect of brain age gap was significant (HR = 1.21, P = 0.047), but its predictive variance was found to overlap entirely with age at ascertainment, consistent with the view that greater brain-age gap and earlier age at onset of prodromal symptoms are correlated indicators of insidious-onset forms of psychosis.
Keywords: Biomarker; Brain age; Clinical high risk; Psychosis prodrome; Risk calculator; Structural MRI.
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Use of Machine Learning to Determine Deviance in Neuroanatomical Maturity Associated With Future Psychosis in Youths at Clinically High RiskY Chung et al. JAMA Psychiatry 75 (9), 960-968. PMID 29971330.These results are consistent with the view that neuroanatomical markers of schizophrenia may help to explain some of the heterogeneity of this disorder, particularly with …
Cortical Abnormalities in Youth at Clinical High-Risk for Psychosis: Findings From the NAPLS2 CohortY Chung et al. Neuroimage Clin 23, 101862. PMID 31150956.In a recent machine learning study classifying "brain age" based on cross-sectional neuroanatomical data, clinical high-risk (CHR) individuals were observed to show devia …
An Individualized Risk Calculator for Research in Prodromal PsychosisTD Cannon et al. Am J Psychiatry 173 (10), 980-988. PMID 27363508.A risk calculator comparable in accuracy to those for cardiovascular disease and cancer is available to predict individualized conversion risks in newly ascertained clini …
Brain Biomarkers of Vulnerability and Progression to PsychosisTD Cannon. Schizophr Bull 42 Suppl 1 (Suppl 1), S127-32. PMID 26656880. - ReviewIdentifying predictors and elucidating the fundamental mechanisms underlying onset of psychosis are critical for the development of targeted preemptive interventions. Thi …
Stress and Neurodevelopmental Processes in the Emergence of PsychosisCW Holtzman et al. Neuroscience 249, 172-91. PMID 23298853. - ReviewThe notion that stress plays a role in the etiology of psychotic disorders, especially schizophrenia, is longstanding. However, it is only in recent years that the potent …