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Adding a Neuroanatomical Biomarker to an Individualized Risk Calculator for Psychosis: A Proof-Of-Concept Study

Adding a Neuroanatomical Biomarker to an Individualized Risk Calculator for Psychosis: A Proof-Of-Concept Study

Yoonho Chung et al. Schizophr Res.

Abstract

In a recent study, a neuroanatomical-based age prediction model observed neuromaturational deviance among clinical high-risk individuals who developed psychosis. Here we aimed to investigate whether incorporating "brain age gap" (discrepancy between neuroanatomical-based predicted age and chronological age) to the North American Prodromal Longitudinal Study risk calculator would enhance prediction of psychosis conversion. The effect of brain age gap was significant (HR = 1.21, P = 0.047), but its predictive variance was found to overlap entirely with age at ascertainment, consistent with the view that greater brain-age gap and earlier age at onset of prodromal symptoms are correlated indicators of insidious-onset forms of psychosis.

Keywords: Biomarker; Brain age; Clinical high risk; Psychosis prodrome; Risk calculator; Structural MRI.

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