Gametocyte density and sex ratio can predict the proportion of mosquitoes that will become infected after feeding on blood of patients receiving nongametocytocidal drugs. Because primaquine and methylene blue sterilize gametocytes before affecting their density and sex ratio, mosquito feeding experiments are required to demonstrate their early transmission-blocking effects.
Keywords: anopheles; infectiousness; malaria; transmission; treatment.
© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.