Microfluidics as an Emerging Precision Tool in Developmental Biology

Dev Cell. 2019 Feb 11;48(3):293-311. doi: 10.1016/j.devcel.2019.01.015.


Microfluidics has become a precision tool in modern biology. It enables omics data to be obtained from individual cells, as compared to averaged signals from cell populations, and it allows manipulation of biological specimens in entirely new ways. Cells and organisms can be perturbed at extraordinary spatiotemporal resolution, revealing mechanistic insights that would otherwise remain hidden. In this perspective article, we discuss the current and future impact of microfluidic technology in the field of developmental biology. In addition, we provide detailed information on how to start using this technology even without prior experience.

Keywords: microfluidics; perturbation; single-cell analysis; spatiotemporal resolution.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Physiological Phenomena / physiology*
  • Cells / cytology*
  • Developmental Biology / methods
  • Humans
  • Microfluidic Analytical Techniques / methods
  • Microfluidics*
  • Spatio-Temporal Analysis*