Comparative effectiveness of teriflunomide and dimethyl fumarate in patients with relapsing forms of MS in the retrospective real-world Teri-RADAR study

J Comp Eff Res. 2019 Apr;8(5):305-316. doi: 10.2217/cer-2018-0135. Epub 2019 Feb 13.

Abstract

Aim: Head-to-head clinical trials of teriflunomide (TFM) versus dimethyl fumarate (DMF) have not been conducted.

Objectives: To compare the real-world effectiveness of TFM versus DMF.

Methods: Anonymized data were collected from patients with relapsing multiple sclerosis (MS) initiating treatment with teriflunomide (N = 50) or DMF (N = 50).

Results: On follow-up magnetic resonance imaging (MRI) compared with baseline, with TFM versus DMF treatment, the proportion of patients with new/enlarging T2 or gadolinium-enhancing lesions was 30.0 versus 40.0% (p = 0.2752). However, median annualized percent whole brain volume change was -0.1 versus -0.5 (p = 0.0212). There were no significant treatment differences on additional MRI and clinical end points and no unexpected safety signals.

Conclusion: The effectiveness of teriflunomide was superior to DMF on whole brain atrophy and similar to DMF on other MRI/clinical end points.

Keywords: MRI; brain volume; dimethyl fumarate; relapsing forms of MS; retrospective study; teriflunomide.

Publication types

  • Clinical Trial, Phase IV
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Brain / pathology
  • Comparative Effectiveness Research
  • Crotonates / administration & dosage
  • Crotonates / adverse effects
  • Crotonates / therapeutic use*
  • Dimethyl Fumarate / administration & dosage
  • Dimethyl Fumarate / adverse effects
  • Dimethyl Fumarate / therapeutic use*
  • Female
  • Humans
  • Immunosuppressive Agents / administration & dosage
  • Immunosuppressive Agents / adverse effects
  • Immunosuppressive Agents / therapeutic use*
  • Longitudinal Studies
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Multiple Sclerosis, Relapsing-Remitting / drug therapy*
  • Retrospective Studies
  • Single-Blind Method
  • Socioeconomic Factors
  • Toluidines / administration & dosage
  • Toluidines / adverse effects
  • Toluidines / therapeutic use*
  • Young Adult

Substances

  • Crotonates
  • Immunosuppressive Agents
  • Toluidines
  • teriflunomide
  • Dimethyl Fumarate