GATA1 epigenetic deregulation contributes to the development of AML with NPM1 and FLT3-ITD cooperating mutations

Leukemia. 2019 Jul;33(7):1827-1832. doi: 10.1038/s41375-019-0399-7. Epub 2019 Feb 12.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomarkers, Tumor / genetics*
  • Epigenesis, Genetic*
  • Female
  • GATA1 Transcription Factor / genetics*
  • GATA1 Transcription Factor / physiology
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Leukemia, Myeloid, Acute / etiology
  • Leukemia, Myeloid, Acute / genetics
  • Leukemia, Myeloid, Acute / pathology*
  • Mice
  • Mice, Knockout
  • Mutation*
  • Nuclear Proteins / genetics*
  • Nucleophosmin
  • Prognosis
  • Tandem Repeat Sequences
  • fms-Like Tyrosine Kinase 3 / genetics*
  • fms-Like Tyrosine Kinase 3 / physiology

Substances

  • Biomarkers, Tumor
  • GATA1 Transcription Factor
  • GATA1 protein, human
  • Gata1 protein, mouse
  • NPM1 protein, human
  • Npm1 protein, mouse
  • Nuclear Proteins
  • Nucleophosmin
  • FLT3 protein, human
  • Flt3 protein, mouse
  • fms-Like Tyrosine Kinase 3