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Review
. 2019 Jan 30;8:F1000 Faculty Rev-123.
doi: 10.12688/f1000research.17163.1. eCollection 2019.

Recent Advances in Our Understanding of the Structure and Function of More Unusual Cation Channels

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Free PMC article
Review

Recent Advances in Our Understanding of the Structure and Function of More Unusual Cation Channels

Brandon M Brown et al. F1000Res. .
Free PMC article

Abstract

As their name implies, cation channels allow the regulated flow of cations such as sodium, potassium, calcium, and magnesium across cellular and intracellular membranes. Cation channels have long been known for their fundamental roles in controlling membrane potential and excitability in neurons and muscle. In this review, we provide an update on the recent advances in our understanding of the structure-function relationship and the physiological and pathophysiological role of cation channels. The most exciting developments in the last two years, in our opinion, have been the insights that cryoelectron microscopy has provided into the inner life and the gating of not only voltage-gated channels but also mechanosensitive and calcium- or sodium-activated channels. The mechanosensitive Piezo channels especially have delighted the field not only with a fascinating new type of structure but with important roles in blood pressure regulation and lung function.

Keywords: cation channel.

Conflict of interest statement

No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.

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References

    1. Hille B: Ion channels of excitable membranes.Sunderland, MA: Sinauer Associates;2001. Reference Source
    1. Alexander SP, Kelly E, Marrion NV, et al. : THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 2017;174(Suppl 1):S1–S16. 10.1111/bph.13882 - DOI - PMC - PubMed
    1. Alexander SP, Striessnig J, Kelly E, et al. : THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Voltage-gated ion channels. Br J Pharmacol. 2017;174(Suppl 1):S160–S194. 10.1111/bph.13884 - DOI - PMC - PubMed
    1. Alexander SP, Peters JA, Kelly E, et al. : THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Ligand-gated ion channels. Br J Pharmacol. 2017;174(Suppl 1):S130–S159. 10.1111/bph.13879 - DOI - PMC - PubMed
    1. Alexander SP, Kelly E, Marrion NV, et al. : THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Other ion channels. Br J Pharmacol. 2017;174(Suppl 1):S195–S207. 10.1111/bph.13881 - DOI - PMC - PubMed

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