Effects of mobilisation with movement (MWM) on anatomical and clinical characteristics of chronic ankle instability: a randomised controlled trial protocol

BMC Musculoskelet Disord. 2019 Feb 13;20(1):75. doi: 10.1186/s12891-019-2447-x.


Background: Up to 40% of individuals who sprain their ankle develop chronic ankle instability (CAI). One treatment option for this debilitating condition is joint mobilisation. There is preliminary evidence that Mulligan's Mobilisation With Movement (MWM) is effective for treating patients with CAI, but the mechanisms by which it works are unclear, with Mulligan suggesting a repositioning of the fibula. This randomised controlled trial aims to determine the effects of MWM on anatomical and clinical characteristics of CAI.

Methods: Participants 18 years or over with CAI will be accepted into the study if they satisfy the inclusion and exclusion criteria endorsed by the International Ankle Consortium. They will be randomised into the experimental group (MWM) or the placebo group (detuned laser) and will receive the assigned intervention over 4 weeks. General joint hypermobility and the presence of mechanical instability of the ankle will be recorded during the first visit. Further, position of the fibula, self-reported function, ankle dorsiflexion range, pressure pain threshold, pain intensity, and static and dynamic balance will be assessed at baseline, and at the conclusion of course of intervention. Follow-up data will be collected at the twelfth week and at the twelfth month following intervention.

Discussion: Effectiveness of MWM on clinically relevant outcomes, including long term benefits will be evaluated. The capacity of MWM to reverse any positional fault of the fibula and the association of any positional fault with other clinically important outcomes for CAI will be explored. Proposed biomechanical mechanisms of fibular positional fault and other neurophysiological mechanisms that may explain the treatment effects of MWM will be further explored. The long term effectiveness of MWM in CAI will also be assessed.

Trial registration: Australian New Zealand Clinical Trials Registry; ACTRN12617001467325 (17/10/2017).

Keywords: Ankle sprain; Chronic ankle instability; Fibular positional fault; Functional instability; Joint mobilisation; Mechanical instability; Mobilisation with movement.

Publication types

  • Clinical Trial Protocol

MeSH terms

  • Ankle Joint / diagnostic imaging
  • Ankle Joint / physiopathology*
  • Biomechanical Phenomena
  • Chronic Disease
  • Exercise Therapy / methods*
  • Humans
  • Joint Instability / diagnostic imaging
  • Joint Instability / physiopathology
  • Joint Instability / therapy*
  • New South Wales
  • Pragmatic Clinical Trials as Topic
  • Range of Motion, Articular
  • Recovery of Function
  • Time Factors
  • Treatment Outcome