Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2019 Feb;98(7):e14422.
doi: 10.1097/MD.0000000000014422.

Proton Pump Inhibitor Use and Risk of Dementia: Systematic Review and Meta-Analysis

Affiliations
Free PMC article
Meta-Analysis

Proton Pump Inhibitor Use and Risk of Dementia: Systematic Review and Meta-Analysis

Min Li et al. Medicine (Baltimore). .
Free PMC article

Abstract

Background: Proton pump inhibitors (PPIs) are an established kind of drugs used to the treatment of most acid-related diseases. Some prospective studies have noticed that PPI use was associated with increased dementia risk. However, the results of those studies were inconsistent and controversial. This meta-analysis aims to determine the association of PPI use and risk of dementia among older people.

Methods: Relevant articles were systematically identified by searching the PubMed, EMBASE, and Cochrane Library databases from inception to February 2018. Cohort studies that reported the risk of dementia or Alzheimer's disease (AD) among PPI users compared with non-PPI users were included. The quality of studies was assessed using the Newcastle-Ottawa Scale (NOS). The publication bias was detected by a funnel plot and Egger test. The meta-analysis will abstract risk estimates including relative risks (RRs), hazard ratios (HRs), and odds ratios (ORs) with a 95% confidence interval (CI) for the associations between PPI use and dementia or Alzheimer's risk. Study-specific results were pooled using a random-effects model.

Results: Six cohort studies were selected finally. The pooled RRs of dementia and AD were 1.23 (95% CI: 0.90-1.67) and 1.01 (95% CI: 0.78-1.32), respectively, compared with those of non-PPI use. The Egger test and funnel plot showed no existence of publication bias. Overall, there was no statistically significant association between PPI use and risk of dementia or AD (P >.05).

Conclusions: This meta-analysis suggests that there was no statistical association between PPIs use and increased risk of dementia or AD.

Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1
Figure 1
Flow chart showing literature search for include cohort studies.
Figure 2
Figure 2
Forest plot of the included studies of the associations between PPIs use and risk of dementia. PPI = proton pump inhibitor.
Figure 3
Figure 3
Forest plot of the included studies of the associations between PPIs use and risk of Alzheimer's disease. PPI = proton pump inhibitor.
Figure 4
Figure 4
Funnel plot for all of this meta-analysis.

Similar articles

See all similar articles

Cited by 1 article

References

    1. Namazi MR, F Jowkar MD. A succinct review of the general and immunological pharmacologic effects of proton pump inhibitors. J Clin Pharm Ther 2008;33:215–7. - PubMed
    1. Simonson W. Do proton pump inhibitors cause dementia. Geriatric Nursing 2016;37:228–9. - PubMed
    1. Schoenfeld AJ, Grady D. Adverse effects associated with proton pump inhibitors. JAMA Intern Med 2016;176:172–4. - PubMed
    1. Heidelbaugh JJ, Goldberg KL, Inadomi JM. Magnitude and economic effect of overuse of antisecretory therapy in the ambulatory care setting. Am J Manag Care 2010;16:228–34. - PubMed
    1. Pasina L, Nobili A, Tettamanti M, et al. Prevalence and appropriateness of drug prescriptions for peptic ulcer and gastro-esophageal reflux disease in a cohort of hospitalized elderly. Eur J Intern Med 2011;22:205–10. - PubMed

Substances

Feedback