Multi-task exclusive relationship learning for alzheimer's disease progression prediction with longitudinal data

Med Image Anal. 2019 Apr;53:111-122. doi: 10.1016/ Epub 2019 Jan 30.


Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive impairment of memory and other cognitive functions. Currently, many multi-task learning approaches have been proposed to predict the disease progression at the early stage using longitudinal data, with each task corresponding to a particular time point. However, the underlying association among different time points in disease progression is still under-explored in previous studies. To this end, we propose a multi-task exclusive relationship learning model to automatically capture the intrinsic relationship among tasks at different time points for estimating clinical measures based on longitudinal imaging data. The proposed method can select the most discriminative features for different tasks and also model the intrinsic relatedness among different time points, by utilizing an exclusive lasso regularization and a relationship induced regularization. Specifically, the exclusive lasso regularization enables partial group structure feature selection among the longitudinal data, while the relationship induced regularization efficiently introduces the relationship information from data to guide knowledge transfer. We further develop an efficient optimization algorithm to solve the proposed objective function. Extensive experiments on both synthetic and real datasets demonstrate the effectiveness of our proposed method. In comparison with several state-of-the-art methods, our proposed method can achieve promising performance for cognitive status prediction and also can help discover disease-related biomarkers.

Keywords: Alzheimer’s disease; Clinical status; Exclusive lasso; Longitudinal analysis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / diagnostic imaging*
  • Alzheimer Disease / pathology
  • Computer Simulation
  • Disease Progression
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Machine Learning*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Predictive Value of Tests